The Napoli star was a member of the Nigerian squad to the 2019 AFCON in Egypt, where he made only one appearance — the third-place match.

He missed out on the delayed AFCON edition in Cameroon in 2022 over COVID-19 related issues, but started off the qualification for the 2023 AFCON in sparkling form helping Nigeria win both of their first two matches.

Osimhen netted a goal against Sierra Leone and another four goals in a 10–0 win against São Tomé and Príncipe. In the reverse fixture at the Godswill Akpabio International Stadium, Uyo on September 10, Osimhen scored his second international hat-trick in Nigeria’s 6–0 win against the minnows, finishing the 2023 AFCON qualifiers as top scorer with 10 goals.